INFIMA is an R package for the Integrative Fine-Mapping with Model Organism Multi-Omics Data. INFIMA utilizes the diversity outbred (DO) mice population as the model organsim. The major usage of the INFIMA package is to fine-map the eQTL markers in DO studies (DO-eQTL). INFIMA implements an empirical Bayes model which quantifies how well each non-coding SNP explains the observed DO allelic patern through consistency of founder mice RNA-seq data, founder mice ATAC-seq data (including the existence and consistency of a footprint) with the observed allelic pattern.